An informative guide to chemotypes, cannabinoids, and terpenes

The Paradigm Shift: From “Indica vs. Sativa” to Chemotypes

For decades, the general understanding of cannabis has been dominated by two terms: Indica and Sativa.

Could a lack of cannabinoids be the real cause of chronic illnesses?

In 2001, Dr. Ethan Russo proposed a groundbreaking theory: clinical endocannabinoid deficiency (CED).

Why do two compounds from the same plant produce such different physiological effects?

The difference between THC and CBD isn’t magic—it’s purely a matter of chemistry. It all comes down to how they interact with the CB1 receptors, which we discussed in our last post.

Endogenous cannabinoids (anandamide & 2-AG)

The human body produces its own cannabinoids.

While the cannabis plant produces phytocannabinoids (such as THC and CBD), our own bodies produce endocannabinoids. The two most important ones are.

Did you know that the human body was already adapted to cannabis long before we even heard of the plant?

Biologically speaking, we all have a “central control system” known as the endocannabinoid system (ECS).